长期专注于生物医学光学成像系统的研发，其中包括荧光寿命成像（FLIm）、近红外漫射散斑对比成像（ScDCT/DSCA）、激光散斑成像（LSCI）、光学相干层析成像（OCT），近红外光谱（NIRS）。在多模态血管内成像、荧光寿命显微成像、可穿戴血氧血流监测以及深层组织血流成像领域积累了系统性的工程研发经验，并与 Intuitive Surgical、BrainLab 等国际知名企业深度合作，推动产品转化。在 Optics Letters, Neurophotonics, IEEE TBME, IEEE TMI 等高水平期刊发表多篇论文，研究成果多次入选 SPIE Photonics West 等重要国际会议。他深度参与美国国立卫生院（ NIH） 多项重大项目，在硬件系统搭建、算法实现、临床场景落地和多单位协作方面积累了丰富经验。

荧光寿命成像，漫射散斑对比成像，激光散斑成像（LSCI）、光学相干层析成像（OCT），近红外光谱（NIRS），多模态血管内成像

1. Liu, X., Bec, J., Zhou, X., Garcia, A. A., & Marcu, L. (2025). Multispectral laser-scanning pulse-sampling fluorescence lifetime system for large-scale tissue imaging. Optics letters. 
2.  Liu, X., Mohtasebi, M., Safavi, P., Fathi, F., Haratbar, S. R., Chen, L., ... & Yu, G. (2024). Wearable fiber-free optical sensor for continuous monitoring of neonatal cerebral blood flow and oxygenation. Pediatric research.
3. Liu, X., Irwin, D. A., Huang, C., Gu, Y., Chen, L., Donohue, K. D., ... & Yu, G. (2022). A wearable fiber-free optical sensor for continuous monitoring of cerebral blood flow in freely behaving mice. IEEE Transactions on Biomedical Engineering, Featured Article.
4. Liu, X., Gu, Y., Huang, C., Zhao, M., Cheng, Y., Jawdeh, E. G. A., ... & Yu, G. (2021). Simultaneous measurements of tissue blood flow and oxygenation using a wearable fiber-free optical sensor. Journal of Biomedical Optics.
5. Akbari, F., Liu, X., Hamedi, F., Mohtasebi, M., Chen, L., Chen, L., & Yu, G. (2025). Programmable scanning diffuse speckle contrast imaging of cerebral blood flow. Neurophotonics.

论文：
1. Liu, X., Bec, J., Zhou, X., Garcia, A. A., & Marcu, L. (2025). Multispectral laser-scanning pulse-sampling fluorescence lifetime system for large-scale tissue imaging. Optics letters. 
2. Akbari, F., Liu, X., Hamedi, F., Mohtasebi, M., Chen, L., Chen, L., & Yu, G. (2025). Programmable scanning diffuse speckle contrast imaging of cerebral blood flow. Neurophotonics. 
3. Liu, X., Mohtasebi, M., Safavi, P., Fathi, F., Haratbar, S. R., Chen, L., ... & Yu, G. (2024). Wearable fiber-free optical sensor for continuous monitoring of neonatal cerebral blood flow and oxygenation. Pediatric research. 
4. Liu, X., Irwin, D. A., Huang, C., Gu, Y., Chen, L., Donohue, K. D., ... & Yu, G. (2022). A wearable fiber-free optical sensor for continuous monitoring of cerebral blood flow in freely behaving mice. IEEE Transactions on Biomedical Engineering, Featured Article by Editor. 
5. Liu, X., Gu, Y., Huang, C., Zhao, M., Cheng, Y., Jawdeh, E. G. A., ... & Yu, G. (2021). Simultaneous measurements of tissue blood flow and oxygenation using a wearable fiber-free optical sensor. Journal of Biomedical Optics. 
6. Rabienia Haratbar, S., Hamedi, F., Mohtasebi, M., Fathi, F., Akbari, F., Liu, X., … & Yu, G. (2025) Noncontact diffuse optical imaging of blood flow and oxygenation distributions in reconstructive rat skin flaps. Biomedical Optics Express.
7. Fathi, F., Mazdeyasna, S., Singh, D., Huang, C., Mohtasebi, M., Liu, X., ... & Yu, G. (2024). Time-resolved laser speckle contrast imaging (TR-LSCI) of cerebral blood flow. IEEE Transactions on Medical Imaging.
8. Rabienia Haratbar, S., Chen, L., Cheng, Q., Singh, D., Fathi, F., Mohtasebi, M., Liu, X., ... & Abu Jawdeh, E. G. (2024). The impact of intermittent hypoxemia on type 1 retinopathy of prematurity in preterm infants. Pediatric Research
9. Mohtasebi, M., Huang, C., Zhao, M., Mazdeyasna, S., Liu, X., Haratbar, S. R., ... & Yu, G. (2023). A wearable fluorescence imaging device for intraoperative identification of human brain tumors. IEEE Journal of Translational Engineering in Health and Medicine
10. Mohtasebi, M., Singh, D., Liu, X., Fathi, F., Haratbar, S. R., Saatman, K. E., ... & Yu, G. (2023). Depth-sensitive diffuse speckle contrast topography for high-density mapping of cerebral blood flow in rodents. Neurophotonics
11. Mohtasebi, M., Irwin, D., Singh, D., Mazdeyasna, S., Liu, X., Haratbar, S. R., ... & Yu, G. (2023). Detection of lowfrequency oscillations in neonatal piglets with speckle contrast diffuse correlation tomography. Journal of Biomedical Optics
著作/教材：
1. D. Irwin, S. Mazdeyasna, C. Huang, M. Mohtasebi, X. Liu, L. Chen & G. Yu (2022). Near-infrared Speckle Contrast Diffuse Correlation Tomography for Noncontact Imaging of Tissue Blood Flow Distribution. CRC Press.
专利申请：
G. Yu, F. Akbari, X. Liu, F. Fathi, M. Mohtasebi, F. Hamed, C. Yeo, “Programmable Scanning Diffuse Speckle Contrast Imaging (PS-DSCI) of Deep Tissue Optical Properties, Hemodynamics, and Function”, US Provisional Patent Application No. 63/570,907, 2023